The Odeon Manchester Great Northern is a 16-screen multiplex cinema at the Great Northern complex on Deansgate in Manchester city centre.

The cinema boasts over 3,000 seats. The biggest theatre can accommodate over 400 cinemagoers. Each screen offers Dolby Digital sound and wheelchair spaces. Several have 3D capabilities.
The box office is situated on the ground floor of the Great Northern. Self-serve ticket machines and an amusement arcade are also here. The theatres and refreshment stand are on the first floor.
Customers travelling by car can park at the NCP Great Northern Warehouse car park. The entrance is on Watson Street (postcode M3 4EE).
Deansgate Train Station and the Deansgate-Castlefield Metrolink Station are just a short walk from the cinema.
The Great Northern is also home to Whistle Punks (axe throwing), the Manchester235 casino, and several bars and restaurants.
The cinema was previously the AMC Manchester. It was taken over by Odeon in the summer of 2017.